Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609182 | 0.89 | HDAC6 (0.59) | HDAC6HDAC1HDAC2PLA2G2AMTNR1A | |
| SCHEMBL4252215 | 0.85 | HDAC6 (0.55) | HDAC6HDAC1HDAC2CHRNB2CHRNA7 | |
| SCHEMBL4255203 | 0.82 | HDAC6 (0.53) | HDAC6HDAC1HDAC2CHRNB2CHRNA7 | |
| SCHEMBL9733129 | 0.80 | PLA2G2A (0.66) | HDAC6HDAC1HDAC2PLA2G2ACHRNB2 | |
| SCHEMBL9733154 | 0.77 | PLA2G2A (0.50) | PLA2G2ACHRNB2CHRNA7CHRNA4HTR6 | |
| SCHEMBL9732896 | 0.77 | PLA2G2A (0.69) | HDAC6HDAC1HDAC2PLA2G2ACHRNB2 | |
| SCHEMBL9732157 | 0.77 | PLA2G2A (0.49) | PLA2G2ACHRNB2CHRNA7CHRNA4HTR6 | |
| SCHEMBL1994325 | 0.74 | HDAC6 (0.67) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL4254173 | 0.72 | HDAC6 (0.75) | HDAC6HDAC1HDAC2MTNR1AMTNR1B | |
| SCHEMBL9732645 | 0.72 | PLA2G2A (0.61) | HDAC6HDAC1HDAC2PLA2G2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC6 11/4885HDAC1 1/4885HDAC2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.