Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446088 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4257476 | 0.83 | RAB9A (0.50) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4251759 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4248121 | 0.79 | LMNA (0.65) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4252170 | 0.75 | HDAC8 (0.52) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4257390 | 0.75 | NPC1 (0.71) | SMN1; SMN2RAB9ANPC1MAPTKMT2A | |
| SCHEMBL4249441 | 0.74 | KMT2A (0.49) | SMN1; SMN2ALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL445319 | 0.73 | RAB9A (0.55) | SMN1; SMN2ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL4258483 | 0.73 | MEN1 (0.54) | SMN1; SMN2ALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL4250461 | 0.73 | NPC1 (0.57) | SMN1; SMN2ALDH1A1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | SMN1; SMN2 3469/4885ALDH1A1 601/4885RAB9A 3763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.