SCHEMBL425178

SCHEMBL425178

CCCCSc1ccccc1N

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.54
PTGS2 P35354 6/20 0.53
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
POLB P06746 1/20 0.48
MAPT P10636 2/20 0.48
NPSR1 Q6W5P4 2/20 0.48
APOBEC3G Q9HC16 1/20 0.48
HSD17B10 Q99714 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.41
S100A4 P26447 1/20 0.41
SOAT1 P35610 1/20 0.41
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1346500 0.94 PTGS2 (0.53) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL11524757 0.92 PTGS2 (0.54) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL9176625 0.92 PTGS2 (0.54) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL9171692 0.92 PTGS2 (0.54) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL9177320 0.92 PTGS2 (0.54) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL3628525 0.87 MEN1 (0.54) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL8672850 0.87 PTGS2 (0.59) TLR8PTGS2MAPTNPSR1ALDH1A1
SCHEMBL28126730 0.85 MEN1 (0.52) TLR8PTGS2MEN1KMT2APOLB
Hydrochloric Acid SCHEMBL16445779 0.85 MEN1 (0.52) TLR8PTGS2MEN1KMT2APOLB
SCHEMBL9696731 0.84 POLB (0.65) TLR8PTGS2MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11804314-B2 Processes for making electrical cables SCHLUMBERGER TECHNOLOGY CORPORATION (US) 2023-10-31 US disclosed
CN-111328423-B Electrical conductors and methods of making and using same 斯伦贝谢技术有限公司 2022-05-03 CN disclosed
US-20210158991-A1 ELECTRICAL CABLES AND PROCESSES FOR MAKING AND USING SAME SCHLUMBERGER TECHNOLOGY CORP (US) 2021-05-27 US disclosed
CN-111328423-A Electrical conductors and methods of making and using same 斯伦贝谢技术有限公司 2020-06-23 CN disclosed
US-10354777-B2 Electrical conductors and processes for making and using same SCHLUMBERGER TECHNOLOGY CORPORATION (US) 2019-07-16 US disclosed
US-20190088386-A1 ELECTRICAL CONDUCTORS AND PROCESSES FOR MAKING AND USING SAME SCHLUMBERGER TECHNOLOGY CORPORATION 2019-03-21 US disclosed
US-20190003278-A1 PACKOFF SEALS AND PROCESSES FOR USING SAME SCHLUMBERGER TECHNOLOGY CORPORATION 2019-01-03 US disclosed
US-20180350488-A1 ELECTRICAL CABLES AND PROCESSES FOR MAKING AND USING SAME SCHLUMBERGER TECHNOLOGY CORPORATION 2018-12-06 US disclosed
US-10000450-B2 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2018-06-19 US disclosed
US-10000450-B2 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2018-06-19 US disclosed
US-4725616-A ANTIARTHRITIC AGENTS PFIZER INC. (US) 1988-02-16 US disclosed
EP-0208510-A2 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents PFIZER INC. (US) 1987-01-14 EP disclosed
US-4567264-A ADRENERGIC BLOCKING AGENTS SYNTEX (U.S.A.) INC. (US) 1986-01-28 US disclosed
US-4558129-A Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade SYNTEX (U.S.A.) INC. (US) 1985-12-10 US disclosed
US-4499100-A CARDIOUVASCULAR DISORDERS SYNTEX (U.S.A.) INC. (US) 1985-02-12 US disclosed
EP-0119428-A2 Biscarboxamides for treating diseases, and process for their preparation BAYER AG (DE) 1984-09-26 EP disclosed
US-4239688-A Herbicidal N-(haloacetyl)-N-(N'-methylenepyrrolidonyl-2-mercaptoalkylanilines GAF CORPORATION (US) 1980-12-16 US disclosed
US-4216152-A Process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines GAF CORPORATION (US) 1980-08-05 US disclosed
US-4203901-A Process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines GAF CORPORATION (US) 1980-05-20 US disclosed
US-4202821-A N-(N'-Methylenepyrrolidonyl)-2-substituted anilines GAF CORPORATION (US) 1980-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10000450-B2 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors SLC6A2, TPH1, SLC6A3 TLR8 4550/4885PTGS2 3295/4885MEN1 2104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.