SCHEMBL4251866

SCHEMBL4251866

O=S(=O)(CS(=O)(=O)c1cccc(Br)c1)c1cccc(Br)c1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PLCG1 P19174 2/20 0.56
ATM Q13315 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.43
MMP2 P08253 2/20 0.43
PGR P06401 1/20 0.41
EGFR P00533 1/20 0.41
ERBB2 P04626 1/20 0.41
KAT6A Q92794 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
MBTD1 Q05BQ5 1/20 0.41
L3MBTL3 Q96JM7 1/20 0.41
BRD4 O60885 1/20 0.41
WDR5 P61964 1/20 0.41
HSD17B2 P37059 1/20 0.41
EDNRB P24530 2/20 0.40
EDNRA P25101 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29068356 0.88 PLCG1 (0.44) PLCG1ATML3MBTL1MMP2PGR
SCHEMBL99072 0.85 PSIP1 (0.56) ATMMMP2PGREGFRERBB2
SCHEMBL17364184 0.83 ATM (0.45) ATML3MBTL1MMP2PGREGFR
SCHEMBL6726327 0.83 ATM (0.45) ATML3MBTL1MMP2PGREGFR
SCHEMBL3600024 0.83 ATM (0.49) PLCG1ATML3MBTL1MMP2PGR
SCHEMBL17699828 0.80 ATM (0.43) ATML3MBTL1MMP2PGREGFR
SCHEMBL28605173 0.80 ATM (0.43) ATML3MBTL1MMP2PGREGFR
SCHEMBL263686 0.80 ATM (0.46) ATML3MBTL1MMP2KAT6AHSD17B2
SCHEMBL20659429 0.80 ATM (0.43) ATML3MBTL1MMP2PGREGFR
SCHEMBL1369921 0.80 CA2 (0.47) ATMMMP2EGFRERBB2KAT6A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7638654-B2 1-fluoro-1, 1-bis-(phenylsulfonyl)methane and production method thereof NAGOYA INSTITUTE OF TECHNOLOGY (JP) 2009-12-29 US disclosed
US-20090131723-A1 1-Fluoro-1,1-Bis-(Phenylsulfonyl)Methane and Production Method Thereof TOSOH F-TECH, INC. (JP) 2009-05-21 US disclosed
EP-1992612-A1 1-FLUORO-1,1-BIS(PHENYLSULFONYL)METHANE AND METHOD FOR PRODUCING SAME NAGOYA INSTITUTE OF TECHNOLOGY (JP) 2008-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131723-A1 1-Fluoro-1,1-Bis-(Phenylsulfonyl)Methane and Production Method Thereof CYP2S1, ARSA, MSMO1 PLCG1 1435/4885ATM 842/4885L3MBTL1 3707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.