Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4256946 | 0.89 | ALDH1A1 (0.56) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL4757822 | 0.89 | ALDH1A1 (0.47) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL1554259 | 0.88 | ALDH1A1 (0.60) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL1553963 | 0.87 | ALDH1A1 (0.50) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL4259340 | 0.87 | NR1H4 (0.39) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL1553328 | 0.85 | ALDH1A1 (0.48) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL1554495 | 0.84 | PTPN1 (0.52) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL4254043 | 0.83 | ALDH1A1 (0.50) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL1553441 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAHPGDMAPTMEN1 | |
| SCHEMBL1553883 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383463-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1383463-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | King Pharmaceuticals, Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002083083-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |