Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | PTPRF | P10586 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPA | Q15257 | 1/20 | 0.49 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554259 | 0.90 | ALDH1A1 (0.60) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL1553441 | 0.89 | ALDH1A1 (0.52) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL1553883 | 0.89 | ALDH1A1 (0.55) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL4252376 | 0.89 | ALDH1A1 (0.53) | ALDH1A1HTTTP53LMNAHPGD | |
| SCHEMBL1554609 | 0.88 | ALDH1A1 (0.49) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL1553140 | 0.86 | TP53 (0.53) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL1554407 | 0.86 | PRKCZ (0.61) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL4563209 | 0.86 | KMT2A (0.42) | ALDH1A1HTTTP53LMNAMAPT | |
| SCHEMBL1554640 | 0.85 | ALDH1A1 (0.63) | ALDH1A1PRKCZHTTTP53LMNA | |
| SCHEMBL4254043 | 0.85 | ALDH1A1 (0.50) | ALDH1A1HTTTP53LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383463-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1383463-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | King Pharmaceuticals, Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002083083-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |