Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 6/20 | 0.55 |
| ▸ | THRB | P10828 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | TACR2 | P21452 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19291196 | 1.00 | THRA (0.55) | THRATHRBALDH1A1ESR1ADRA2A | |
| SCHEMBL13422217 | 0.89 | PPARA (0.48) | THRATHRBALDH1A1 | |
| SCHEMBL13783933 | 0.86 | ALDH1A1 (0.59) | THRATHRBALDH1A1ESR1ADRA2A | |
| SCHEMBL23266209 | 0.86 | ALDH1A1 (0.59) | THRATHRBALDH1A1LMNATP53 | |
| Dodecylacetate SCHEMBL28973893 | 0.86 | ALDH1A1 (0.65) | THRATHRBALDH1A1ESR1ADRA2A | |
| Octyl Acetate SCHEMBL4379323 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNATP53CYP3A4 | |
| SCHEMBL8715648 | 0.85 | RARB (0.64) | THRATHRBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18643851 | 0.85 | MAPT (0.62) | THRATHRBALDH1A1ESR1LMNA | |
| SCHEMBL4293988 | 0.85 | THRA (0.57) | THRATHRB | |
| SCHEMBL8501592 | 0.85 | THRA (0.57) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978154-A | Preparation method of 4-octyl phenethyl alcohol | 南京康德祥医药科技有限公司 | 2020-11-24 | — | — | CN | disclosed |
| EP-2807143-B1 | PROCESS FOR PREPARATION OF FINGOLIMOD | GLENMARK GENERICS LTD (IN) | 2017-08-30 | — | — | EP | disclosed |
| US-9216943-B2 | Preparation of fingolimod and its salts | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-12-22 | — | — | US | disclosed |
| US-9056813-B2 | Process for preparation of fingolimod | GLENMARK GENERICS LIMITED (IN) | 2015-06-16 | — | — | US | disclosed |
| US-20140235895-A1 | PREPARATION OF FINGOLIMOD AND ITS SALTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-08-21 | — | — | US | disclosed |
| WO-2014118556-A2 | SELECTIVE INHIBITORS AND ALLOSTERIC ACTIVATORS OF SPHINGOSINE KINASE | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-07 | — | — | WO | disclosed |
| WO-2014118556-A2 | SELECTIVE INHIBITORS AND ALLOSTERIC ACTIVATORS OF SPHINGOSINE KINASE | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-07 | — | — | WO | disclosed |
| US-8735627-B2 | Intermediate compounds and process for the preparation of fingolimod | MAPI PHARMA LTD. (IL) | 2014-05-27 | — | — | US | disclosed |
| EP-2702034-A2 | PREPARATION OF FINGOLIMOD AND ITS SALTS | Dr. Reddy's Laboratories Ltd. (IN) | 2014-03-05 | — | — | EP | disclosed |
| US-20130217899-A1 | INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF FINGOLIMOD | MAPI PHARMA LTD. (IL) | 2013-08-22 | — | — | US | disclosed |
| US-20090264469-A1 | NOVEL DICARBOXYLIC ACID DERIVATIVES | BIO-PROJET (FR) | 2009-10-22 | — | — | US | disclosed |
| US-20090264469-A1 | NOVEL DICARBOXYLIC ACID DERIVATIVES | BIO-PROJET (FR) | 2009-10-22 | — | — | US | disclosed |
| US-20090264469-A1 | NOVEL DICARBOXYLIC ACID DERIVATIVES | BIO-PROJET (FR) | 2009-10-22 | — | — | US | disclosed |
| WO-2006043149-A9 | NOVEL DICARBOXYLIC ACID DERIVATIVES | BIOPROJET SOC CIV (FR) | 2006-08-10 | — | — | WO | disclosed |
| WO-2006043149-A2 | NOVEL DICARBOXYLIC ACID DERIVATIVES | BIOPROJET (FR) | 2006-04-27 | — | — | WO | disclosed |
| US-5952316-A | FOR TREATING AUTOIMMUNE DISEASES, E.G., RHEUMATIOD ARTHRITIS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0627406-B1 | 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT | YOSHITOMI PHARMACEUTICAL (JP) | 1998-10-28 | — | — | EP | disclosed |
| US-5719176-A | 2-amino-1,3-propanediol compound and immunosuppressant | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5604229-A | 2-amino-1,3-propanediol compound and immunosuppressant | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-18 | — | — | US | disclosed |
| EP-0627406-A1 | 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217899-A1 | INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF FINGOLIMOD | S1PR2, S1PR4, S1PR3 | THRA 3775/4885THRB 3565/4885ALDH1A1 738/4885 |
| US-20090264469-A1 | NOVEL DICARBOXYLIC ACID DERIVATIVES | S1PR2, S1PR1, S1PR5 | THRA 973/4885THRB 965/4885ALDH1A1 1287/4885 |
| US-20140235895-A1 | PREPARATION OF FINGOLIMOD AND ITS SALTS | S1PR4, S1PR2, S1PR1 | THRA 2423/4885THRB 2954/4885ALDH1A1 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.