Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465327 | 0.88 | NPC1 (0.46) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL3363096 | 0.81 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDGLA | |
| SCHEMBL3176511 | 0.79 | LTA4H (0.40) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL5516669 | 0.78 | NPC1 (0.53) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| Hydrochloric Acid SCHEMBL12004262 | 0.77 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL10823971 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL7569351 | 0.76 | TGFBR1 (0.45) | KDM4ESMN1; SMN2ALDH1A1HPGDGLA | |
| Bromide SCHEMBL12003693 | 0.76 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL31500784 | 0.75 | SMN1; SMN2 (0.50) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL30596386 | 0.75 | KDM4E (0.61) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648462-A4 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2009-04-08 | — | — | EP | claimed |
| JP-2007535477-A | — | — | 2007-12-06 | — | — | JP | claimed |
| EP-1648462-A1 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009440-A1 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-02-03 | — | — | WO | claimed |