SCHEMBL4253035

SCHEMBL4253035

CC(C)(C)Sc1ccc(C#Cc2ccc(C#Cc3ccc(SC(C)(C)C)cc3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 1/20 0.44
KDM4E B2RXH2 2/20 0.41
HSD17B10 Q99714 1/20 0.41
AR P10275 1/20 0.39
APP P05067 5/20 0.36
ACACB O00763 1/20 0.36
GRM5 P41594 1/20 0.35
RARB P10826 1/20 0.35
RARG P13631 1/20 0.35
KCNH2 Q12809 4/20 0.33
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
CYP2C19 P33261 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18245275 0.87 SLC6A4 (0.39) SLC6A4KDM4EHSD17B10AR
SCHEMBL4252316 0.83 KDM4E (0.38) SLC6A4KDM4EHSD17B10AR
SCHEMBL5117424 0.81 AR (0.49) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL21100519 0.76 SLC6A4 (0.48) SLC6A4KDM4EHSD17B10ARMEN1
SCHEMBL6001741 0.75 ALDH1A1 (0.56) KDM4EAPPKCNH2ALDH1A1RAB9A
SCHEMBL333951 0.74 SLC6A4 (0.47) SLC6A4KDM4EHSD17B10ARMEN1
SCHEMBL13923556 0.74 SLC6A4 (0.47) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL5546729 0.72 SLC6A4 (0.45) SLC6A4KDM4EHSD17B10ARMEN1
SCHEMBL2480563 0.72 NR1H2 (0.50) SLC6A4KDM4EHSD17B10ARMEN1
SCHEMBL7937564 0.72 SLC6A4 (0.45) SLC6A4KDM4EHSD17B10ARMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009134227-A1 POL YARYLENE POLYMERS RESULTING FROM DIELS-ALDER REACTION ENERGY MATERIALS CORPORATION (US) 2009-11-05 WO disclosed
US-20090264544-A1 Polyarylene polymers and ion conducting functionalized polyarylene polymers resulting from pairing bis-diene arylenes and bis-dienophile arylenes via a diels-alder reaction ENERGY MATERIALS CORPORATION 2009-10-22 US disclosed