SCHEMBL5546729

SCHEMBL5546729

CC(C)(C)Sc1ccc([O])cc1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 1/20 0.45
KDM4E B2RXH2 2/20 0.42
HSD17B10 Q99714 1/20 0.42
AR P10275 1/20 0.36
ALDH1A1 P00352 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21100519 0.78 SLC6A4 (0.48) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL202010 0.77 SLC6A4 (0.32) SLC6A4
SCHEMBL333951 0.76 SLC6A4 (0.47) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL13923556 0.76 SLC6A4 (0.47) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL199651 0.75 SLC6A4 (0.32) SLC6A4
SCHEMBL3046643 0.74 ALDH1A1 (0.58) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL2480563 0.74 NR1H2 (0.50) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL518851 0.74 ALDH1A1 (0.58) KDM4EALDH1A1TDP1LMNAHTT
SCHEMBL7937564 0.74 SLC6A4 (0.45) SLC6A4KDM4EHSD17B10ARALDH1A1
SCHEMBL2737144 0.74 SLC6A4 (0.45) SLC6A4KDM4EHSD17B10ARALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2570418-A2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-20 EP disclosed
EP-1555267-B1 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES OTSUKA PHARMA CO LTD (JP) 2013-01-16 EP disclosed
US-7262212-B2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-08-28 US disclosed
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-05-04 US disclosed
EP-1555267-A1 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-07-20 EP disclosed
US-6627714-B2 Copolymerizing ethylene and dicyclopentadiene or tricyclopentadiene, and cyclic olefin in presence of metallocene catalyst to produce copolymer MARUZEN PETROCHEMICAL CO., LTD. (JP) 2003-09-30 US disclosed
US-20020058767-A1 Method for producing an olefin type copolymer having a cyclic structure MARUZEN PETROCHEMICAL CO., LTD. (JP) 2002-05-16 US disclosed
EP-1205497-A2 Method for producing an olefin type copolymer having a cyclic structure MARUZEN PETROCHEMICAL CO., LTD. (JP) 2002-05-15 EP disclosed
US-4069377-A Polymerization of ethylenically unsaturated monomers employing secondary-aliphatic α-substituted azoalkanes PENNWALT CORPORATION 1978-01-17 US disclosed
US-4025502-A POLYMERIZATION CATALYSTS, CURING AGENTS PENNWALT CORPORATION (US) 1977-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles NR2C2, NR4A3, NR4A2 SLC6A4 4191/4885KDM4E 4854/4885HSD17B10 467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.