Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75717 | 1.00 | HSD11B1 (0.34) | HSD11B1CHRM2CHRM3CNR2ALDH1A1 | |
| SCHEMBL4255753 | 0.91 | CNR2 (0.34) | HSD11B1CNR2ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL76306 | 0.90 | CNR2 (0.31) | HSD11B1CNR2ALDH1A1LMNA | |
| SCHEMBL4264917 | 0.90 | CNR2 (0.31) | HSD11B1CNR2ALDH1A1LMNA | |
| SCHEMBL4257970 | 0.87 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL75434 | 0.87 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL1574084 | 0.85 | HSD11B1 (0.35) | HSD11B1CNR2SMN1; SMN2 | |
| SCHEMBL4251570 | 0.85 | HSD11B1 (0.35) | HSD11B1CNR2SMN1; SMN2 | |
| SCHEMBL75020 | 0.83 | HSD11B1 (0.31) | HSD11B1CNR2ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL4253053 | 0.83 | CNR2 (0.40) | HSD11B1CNR2ALDH1A1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |