Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261059 | 0.89 | TSHR (0.43) | TSHRL3MBTL1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4254000 | 0.85 | HMGCR (0.33) | CYP3A4CYP2C9CYP2C19HMGCRCA12 | |
| SCHEMBL2546298 | 0.80 | CYP1A2 (0.34) | TSHRCYP3A4CYP2C9CYP2C19HMGCR | |
| SCHEMBL2539469 | 0.79 | ENPP2 (0.33) | TSHRCYP3A4ENPP2POLB | |
| SCHEMBL11345116 | 0.78 | GAA (0.41) | TSHRL3MBTL1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1846885 | 0.77 | FFAR4 (0.44) | TSHRALDH1A1LMNAHSD17B10 | |
| SCHEMBL328890 | 0.77 | TSHR (0.48) | TSHRL3MBTL1ALDH1A1LMNA | |
| SCHEMBL9030324 | 0.76 | L3MBTL1 (0.43) | TSHRL3MBTL1ALDH1A1LMNAENPP2 | |
| SCHEMBL1852629 | 0.76 | PPARD (0.43) | TSHRCYP3A4CYP2C9CYP2C19HMGCR | |
| SCHEMBL15981052 | 0.76 | TSHR (0.37) | TSHRHMGCRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097440-A1 | PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | Targanta Therapeutics Inc. (CA) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008077241-A1 | PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS, INC. (CA) | 2008-07-03 | — | — | WO | disclosed |