Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.52 |
| ▸ | SI | P14410 | 1/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413639 | 0.84 | ALDH1A1 (0.87) | ALDH1A1TSHRSMN1; SMN2GAAHSD17B10 | |
| SCHEMBL9505147 | 0.83 | ADRA2A (0.51) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL7817206 | 0.81 | KDM4E (0.88) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL10617897 | 0.80 | ADRA2A (0.59) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL5342395 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL2999858 | 0.78 | KDM4E (0.65) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL14413641 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TSHRSMN1; SMN2LMNAGAA | |
| SCHEMBL11379013 | 0.77 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL3032293 | 0.77 | KDM4E (0.80) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL3038503 | 0.76 | ABCC1 (0.72) | ALDH1A1KDM4EHPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045428-B2 | Substituted heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2015-06-02 | — | — | US | claimed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |