Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4254389 | 0.97 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2 | |
| SCHEMBL2263815 | 0.75 | HSD17B10 (0.54) | HSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4347112 | 0.73 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2 | |
| SCHEMBL2692984 | 0.69 | KDM4E (0.31) | SMN1; SMN2 | |
| SCHEMBL3132852 | 0.69 | — | — | |
| SCHEMBL503928 | 0.67 | — | — | |
| SCHEMBL10453358 | 0.67 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL1876188 | 0.66 | CRBN (0.32) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3022081 | 0.66 | HTR2A (0.39) | — | |
| SCHEMBL1058536 | 0.65 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| US-9938292-B2 | Quinoline derivatives as SMO inhibitors | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-10 | — | — | US | disclosed |
| US-9938292-B2 | Quinoline derivatives as SMO inhibitors | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-10 | — | — | US | disclosed |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-06-22 | — | — | US | disclosed |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-06-22 | — | — | US | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015144001-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | 南京明德新药研发股份有限公司 | 2015-10-01 | — | — | WO | disclosed |
| US-7608630-B2 | Prepared by extracting fungi Marasmius androsaceus L.es Fr with an organic solvent, an aqueous organic solvent or water, and concentrating the obtained extractive; use in treatment of cardiovascular disorders | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2009-10-27 | — | — | US | disclosed |
| US-7608630-B2 | Prepared by extracting fungi Marasmius androsaceus L.es Fr with an organic solvent, an aqueous organic solvent or water, and concentrating the obtained extractive; use in treatment of cardiovascular disorders | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2009-10-27 | — | — | US | disclosed |
| US-7608630-B2 | Prepared by extracting fungi Marasmius androsaceus L.es Fr with an organic solvent, an aqueous organic solvent or water, and concentrating the obtained extractive; use in treatment of cardiovascular disorders | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2009-10-27 | — | — | US | disclosed |
| US-20090253742-A1 | MARASMIUS ANDROSACEUS L.ES FR EXTRACT, PIPERIDONE DERIVATIVE, AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVES | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2009-10-08 | — | — | US | disclosed |
| US-20090253742-A1 | MARASMIUS ANDROSACEUS L.ES FR EXTRACT, PIPERIDONE DERIVATIVE, AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVES | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2009-10-08 | — | — | US | disclosed |
| US-20090253742-A1 | MARASMIUS ANDROSACEUS L.ES FR EXTRACT, PIPERIDONE DERIVATIVE, AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVES | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2009-10-08 | — | — | US | disclosed |
| US-20070160625-A1 | Marasmius androsaceus l.es fr extract, piperidone derivative, and their use for the preparation of antihypertensives | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2007-07-12 | — | — | US | disclosed |
| US-20070160625-A1 | Marasmius androsaceus l.es fr extract, piperidone derivative, and their use for the preparation of antihypertensives | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2007-07-12 | — | — | US | disclosed |
| US-20070160625-A1 | Marasmius androsaceus l.es fr extract, piperidone derivative, and their use for the preparation of antihypertensives | HAINAN YANGPU NEW SPECIAL PHARMACEUTICAL CO., LTD. (CN) | 2007-07-12 | — | — | US | disclosed |
| CN-1918123-A | Marasmius androsaceus extract, piperidone derivative and application thereof in preparation of antihypertensive drugs | TUOLIN MEDICINE TECH CO LTD BE (CN) | 2007-02-21 | — | — | CN | disclosed |
| EP-1710235-A1 | EXTRACTS OF MARASMINS ANDROSACEUS L.ES, PIPERDINONE DERIVATIVES AND THE USE AS ANTIHYPERTENSIVE AGENTS | Beijing Tuolin Medicine Science and Technology Co., Ltd. (CN) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253742-A1 | MARASMIUS ANDROSACEUS L.ES FR EXTRACT, PIPERIDONE DERIVATIVE, AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVES | REN, PTGIS, EDNRA | HSD17B10 1579/4885SMN1; SMN2 2532/4885 |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | SMO, GLI1, SHH | HSD17B10 2934/4885SMN1; SMN2 4029/4885 |
| US-20070160625-A1 | Marasmius androsaceus l.es fr extract, piperidone derivative, and their use for the preparation of antihypertensives | REN, PTGIS, EDNRA | HSD17B10 1579/4885SMN1; SMN2 2532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.