Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3296501 | 1.00 | HTR6 (0.51) | HTR6HTR1AHTR3EHTR3BCYP1A2 | |
| SCHEMBL3296452 | 0.79 | HTR6 (0.48) | HTR6HTR1AHTR3EHTR3BCYP1A2 | |
| SCHEMBL3300081 | 0.78 | GABRA1 (0.42) | HTR6HTR1AKDM4EALDH1A1SLC6A4 | |
| SCHEMBL13298381 | 0.77 | HTR6 (0.50) | HTR6HTR1AHTR3EHTR3BCYP1A2 | |
| SCHEMBL9272779 | 0.72 | HTR6 (0.52) | HTR6HTR1AHTR3EHTR3BCYP1A2 | |
| SCHEMBL7745979 | 0.71 | KDM4E (0.57) | CYP1A2TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL3297914 | 0.70 | HTR6 (0.55) | HTR6HTR1AHTR3EHTR3BCYP1A2 | |
| SCHEMBL3300141 | 0.68 | HTR6 (0.44) | HTR6HTR1ANCF1HTR3AKDM4E | |
| SCHEMBL23632364 | 0.67 | NPC1 (0.61) | HTR6HSD17B10KDM4EALDH1A1 | |
| SCHEMBL28336625 | 0.67 | HTR6 (0.58) | HTR6HTR1AHTR3EHTR3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084131-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |