Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248456 | 0.83 | ALDH1A1 (0.30) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL3822149 | 0.82 | HTR6 (0.35) | HTR6TRPM5HDAC1HDAC6ALDH1A1 | |
| SCHEMBL3526525 | 0.78 | DRD2 (0.41) | — | |
| SCHEMBL3524800 | 0.77 | NOTUM (0.44) | HTR6HDAC1HDAC6TRPV1 | |
| SCHEMBL3530367 | 0.75 | NOTUM (0.40) | TRPM5MTNR1AMTNR1BALDH1A1MEN1 | |
| SCHEMBL3526848 | 0.75 | HDAC1 (0.40) | TRPM5HDAC1HDAC6ALDH1A1MEN1 | |
| SCHEMBL3530642 | 0.75 | NOTUM (0.39) | TRPM5ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL3524887 | 0.72 | HDAC1 (0.49) | HDAC1HDAC6 | |
| SCHEMBL3823511 | 0.71 | FNTA (0.38) | HTR6TRPM5HDAC1HDAC6MAPT | |
| SCHEMBL3529275 | 0.71 | NOTUM (0.39) | HTR6TRPM5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084152-A2 | SUBSTITUTED 4-IMIDAZOLES | F. Hoffmann-Roche AG (CH) | 2009-08-05 | — | — | EP | claimed |
| WO-2008058867-A2 | SUBSTITUTED 4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-22 | — | — | WO | claimed |