SCHEMBL4255502

SCHEMBL4255502

COc1cc(C=C(C(=O)O)c2ccc(C=Cc3cc(OC(C)=O)cc(OC(C)=O)c3)cc2)ccc1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.53
KDM4E B2RXH2 3/20 0.52
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
MAPT P10636 2/20 0.52
TTR P02766 2/20 0.52
LMNA P02545 1/20 0.52
TP53 P04637 1/20 0.52
CYP3A4 P08684 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
CYP19A1 P11511 1/20 0.52
TUBB4A P04350 2/20 0.52
TUBB P07437 2/20 0.52
TUBA3C P0DPH7 2/20 0.52
TUBA1B P68363 2/20 0.52
TUBA4A P68366 2/20 0.52
TUBB4B P68371 2/20 0.52
TUBB3 Q13509 2/20 0.52
TUBB2A Q13885 2/20 0.52
TUBB8 Q3ZCM7 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4255498 1.00 ALOX5 (0.53) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL4261075 0.90 AKR1C3 (0.56) KDM4EMEN1KMT2AMAPTTTR
SCHEMBL4261082 0.90 AKR1C3 (0.56) KDM4EMEN1KMT2AMAPTTTR
SCHEMBL4252802 0.85 MEN1 (0.62) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL4252807 0.85 MEN1 (0.62) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL14125351 0.82 CXCL12 (0.62) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL14125352 0.82 CXCL12 (0.62) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL4257978 0.81 MEN1 (0.63) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL4254123 0.81 MEN1 (0.63) ALOX5KDM4EMEN1KMT2AMAPT
SCHEMBL31510188 0.80 AKR1C3 (0.66) KDM4EMEN1KMT2ATUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9067908-B2 Polyphenolic bioprecursors RHODIA CHIMIE (FR) 2015-06-30 US disclosed
EP-1893555-B1 POLYPHENOL-BASED BIOPRECURSOR RHODIA CHIMIE SA (FR) 2014-10-29 EP disclosed
US-20090215881-A1 Polyphenolic Bioprecursors CHIMIE, Rhodia Chime (FR) 2009-08-27 US disclosed
EP-1893555-A1 POLYPHENOL-BASED BIOPRECURSOR RHODIA CHIMIE (FR) 2008-03-05 EP disclosed
WO-2006134282-A1 POLYPHENOL-BASED BIOPRECURSOR RHODIA CHIMIE (FR) 2006-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215881-A1 Polyphenolic Bioprecursors PPARG, PPARA, FABP4 ALOX5 249/4885KDM4E 1867/4885MEN1 4026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.