SCHEMBL4257978

SCHEMBL4257978

COc1cc(C(=O)Oc2ccc(C=Cc3cc(OC(C)=O)cc(OC(C)=O)c3)cc2)ccc1O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.63
KMT2A Q03164 3/20 0.63
LMNA P02545 2/20 0.63
MAPT P10636 2/20 0.63
TTR P02766 2/20 0.63
KDM4E B2RXH2 1/20 0.63
TP53 P04637 1/20 0.63
CYP3A4 P08684 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
TUBB4A P04350 2/20 0.58
TUBB P07437 2/20 0.58
TUBA3C P0DPH7 2/20 0.58
TUBA1B P68363 2/20 0.58
TUBA4A P68366 2/20 0.58
TUBB4B P68371 2/20 0.58
TUBB3 Q13509 2/20 0.58
TUBB2A Q13885 2/20 0.58
TUBB8 Q3ZCM7 2/20 0.58
TUBA3E Q6PEY2 2/20 0.58
TUBA1A Q71U36 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254123 1.00 MEN1 (0.63) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4254083 0.85 MAPT (0.69) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4263564 0.85 MAPT (0.69) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4259090 0.84 MAPT (0.63) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4259088 0.84 MAPT (0.63) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4255499 0.84 MAPT (0.63) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4255498 0.81 ALOX5 (0.53) MEN1KMT2ALMNAMAPTTTR
SCHEMBL4255502 0.81 ALOX5 (0.53) MEN1KMT2ALMNAMAPTTTR
SCHEMBL22315415 0.79 TTR (0.87) MEN1KMT2ALMNAMAPTTTR
SCHEMBL18121564 0.79 KMT2A (0.62) MEN1KMT2ALMNAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9067908-B2 Polyphenolic bioprecursors RHODIA CHIMIE (FR) 2015-06-30 US claimed
US-20090215881-A1 Polyphenolic Bioprecursors CHIMIE, Rhodia Chime (FR) 2009-08-27 US claimed
EP-1893555-A1 POLYPHENOL-BASED BIOPRECURSOR RHODIA CHIMIE (FR) 2008-03-05 EP claimed
WO-2006134282-A1 POLYPHENOL-BASED BIOPRECURSOR RHODIA CHIMIE (FR) 2006-12-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215881-A1 Polyphenolic Bioprecursors PPARG, PPARA, FABP4 MEN1 4026/4885KMT2A 2120/4885LMNA 3029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.