Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2973520 | 0.99 | JAK2 (0.44) | JAK2JAK3PTK2HPGDSCYP1B1 | |
| SCHEMBL4262081 | 0.87 | CYP1A1 (0.59) | HPGDSCYP1B1CYP1A1HTR2CMEN1 | |
| Bromide SCHEMBL2985795 | 0.86 | CYP1A1 (0.57) | HPGDSCYP1B1CYP1A1HTR2CMEN1 | |
| SCHEMBL2981407 | 0.82 | NPC1 (0.41) | CYP1B1CYP1A1MEN1KMT2ANPC1 | |
| SCHEMBL2979646 | 0.81 | ALDH1A1 (0.42) | CYP1B1CYP1A1NPC1RAB9AEIF4E | |
| SCHEMBL4257174 | 0.80 | RAB9A (0.60) | HPGDSCYP1B1CYP1A1MEN1KMT2A | |
| SCHEMBL5072503 | 0.80 | ALDH1A1 (0.36) | JAK2JAK3PTK2NPC1RAB9A | |
| SCHEMBL27713695 | 0.80 | HPGDS (0.45) | JAK2JAK3PTK2HPGDSHTR2C | |
| SCHEMBL2981957 | 0.80 | ALDH1A1 (0.40) | JAK2JAK3PTK2CYP1B1CYP1A1 | |
| Bromide SCHEMBL2972856 | 0.79 | NPC1 (0.62) | HPGDSCYP1B1CYP1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |