SCHEMBL4256341

SCHEMBL4256341

Cc1ccc(S(=O)(=O)N2CCC3(CC2)CN(Cc2ccc(C#N)cc2)C(=O)O3)cc1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.46
USP2 O75604 3/20 0.46
ALDH1A1 P00352 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
MEN1 O00255 1/20 0.46
MAPK1 P28482 1/20 0.46
KMT2A Q03164 1/20 0.46
HIF1A Q16665 1/20 0.46
CYP2D6 P10635 4/20 0.44
TSHR P16473 2/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
PKM P14618 1/20 0.40
PKLR P30613 1/20 0.40
CNR1 P21554 1/20 0.40
CYP1A2 P05177 1/20 0.40
HTR7 P34969 1/20 0.39
FASN P49327 1/20 0.38
GAA P10253 1/20 0.38
NR3C1 P04150 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1085966 0.88 USP2 (0.51) CYP3A4USP2ALDH1A1SMN1; SMN2MEN1
SCHEMBL4265188 0.87 MAPT (0.43) ALDH1A1MEN1KMT2ATSHRGAA
SCHEMBL1086685 0.77 PKM (0.50) CYP3A4USP2ALDH1A1SMN1; SMN2MEN1
SCHEMBL1086606 0.75 ALDH1A1 (0.48) USP2ALDH1A1SMN1; SMN2PKM
SCHEMBL12184670 0.74 PRKAA2 (0.51) CYP3A4USP2ALDH1A1SMN1; SMN2MEN1
SCHEMBL1085842 0.74 CYP2D6 (0.48) CYP3A4USP2ALDH1A1SMN1; SMN2MEN1
SCHEMBL1086223 0.74 HSD11B1 (0.50) ALDH1A1MEN1KMT2ATSHRGAA
SCHEMBL1085986 0.73 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2
SCHEMBL1085854 0.73 HPGD (0.44) CYP3A4USP2ALDH1A1SMN1; SMN2MEN1
SCHEMBL1086549 0.72 GAA (0.47) USP2ALDH1A1MEN1MAPK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-B1 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-06-03 EP claimed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP claimed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO claimed
EP-1910381-B1 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-06-03 EP disclosed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP disclosed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO disclosed