Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Peroxide SCHEMBL5367632 | 0.91 | ALDH1A1 (0.48) | LMNAALDH1A1HSD17B10TP53ALOX15 | |
| Propionic Acid SCHEMBL9398083 | 0.88 | FFAR3 (0.48) | LMNAEGLN1ALDH1A1FFAR3HSD17B10 | |
| Bicarbonate SCHEMBL28391088 | 0.88 | ALDH1A1 (0.46) | LMNAALDH1A1HSD17B10TP53ALOX15 | |
| SCHEMBL284806 | 0.88 | — | — | |
| SCHEMBL22598 | 0.88 | — | — | |
| SCHEMBL344175 | 0.88 | — | — | |
| SCHEMBL471892 | 0.88 | ALDH1A1 (0.50) | LMNAALDH1A1HSD17B10TP53ALOX15 | |
| SCHEMBL29615225 | 0.88 | — | — | |
| Glycolic Acid SCHEMBL28158225 | 0.86 | ALDH1A1 (0.40) | LMNAEGLN1ALDH1A1FFAR3HSD17B10 | |
| Hexanoate SCHEMBL28713510 | 0.86 | AKR1B1 (0.59) | LMNAALDH1A1HSD17B10CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8613780-B2 | Process for producing mixed esters of fatty acids as biofuels | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2013-12-24 | — | — | US | disclosed |
| US-20090126262-A1 | Process for producing mixed esters of fatty acids as biofuels | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-05-21 | — | — | US | disclosed |