Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | HTR3A | P46098 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510914 | 0.91 | KDM4E (0.65) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL4252121 | 0.90 | MAPT (0.68) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL4254375 | 0.90 | ALDH1A1 (0.72) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL2118623 | 0.90 | ALDH1A1 (0.69) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL4253715 | 0.89 | HTR3A (0.67) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL4253579 | 0.89 | GAA (0.65) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL27203155 | 0.85 | ALDH1A1 (0.61) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL7194154 | 0.84 | HPGD (0.59) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL4258648 | 0.83 | GAA (0.63) | GAATP53ALDH1A1HTTKDM4E | |
| SCHEMBL7655012 | 0.82 | KDM4E (0.72) | GAATP53ALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748422-B2 | Pharmaceutical compositions containing quinazoline derivatives for treating as serotonin receptor antagonist | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-06-10 | — | — | US | disclosed |
| US-20090054433-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING QUINAZOLINE DERIVATIVES FOR TREATING AS SEROTONIN RECEPTOR ANTAGONIST | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-02-26 | — | — | US | disclosed |
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054433-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING QUINAZOLINE DERIVATIVES FOR TREATING AS SEROTONIN RECEPTOR ANTAGONIST | HTR3A, HTR3B, HTR3E | GAA 865/4885TP53 4443/4885ALDH1A1 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.