Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4256747 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4266446 | 0.92 | ALOX12 (0.39) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4266450 | 0.92 | ALOX12 (0.39) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4262718 | 0.88 | MCHR1 (0.38) | HTTKMT2AMCHR1ADRA2AHRH1 | |
| SCHEMBL4262726 | 0.88 | MCHR1 (0.38) | HTTKMT2AMCHR1ADRA2AHRH1 | |
| SCHEMBL4263765 | 0.85 | CRHR1 (0.41) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4263758 | 0.85 | CRHR1 (0.41) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4258493 | 0.81 | MCHR1 (0.40) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4258486 | 0.81 | MCHR1 (0.40) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 | |
| SCHEMBL4256563 | 0.81 | CRHR1 (0.39) | SMN1; SMN2ALDH1A1CACNA1BAPBA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | claimed |
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | SMN1; SMN2 898/4885ALDH1A1 765/4885CACNA1B 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.