Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14993457 | 0.88 | CYP3A4 (0.53) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL2811810 | 0.86 | CYP3A4 (0.78) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL5624918 | 0.80 | CYP3A4 (0.71) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL14992580 | 0.80 | SMN1; SMN2 (0.46) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL4263528 | 0.79 | CYP3A4 (0.71) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| Xanthoxylin SCHEMBL44708 | 0.79 | CYP3A4 (1.00) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| Xanthoxylin SCHEMBL29349586 | 0.79 | CYP3A4 (1.00) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL30916607 | 0.79 | CYP3A4 (0.71) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL15904569 | 0.78 | TYK2 (0.45) | CYP3A4MAPK1USP2SMN1; SMN2POLB | |
| SCHEMBL8648084 | 0.78 | HPGD (0.59) | CYP3A4MAPK1USP2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | CORBETT JEFFREY WAYNE | 2009-10-29 | — | — | US | disclosed |
| EP-2097420-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008065508-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| EP-0248420-B1 | BENZOPYRAN DERIVATIVES | DAIICHI SEIYAKU CO., LTD. (JP) | 1991-09-18 | — | — | EP | disclosed |
| EP-0415566-A1 | Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4841076-A | DIURETICS, HYPOTENSIVE AGENTS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| EP-0248420-A2 | Benzopyran derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1987-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, PC, ACACB | CYP3A4 1414/4885MAPK1 1428/4885USP2 3839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.