Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.55 |
| ▸ | CCR1 | P32246 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CCR4 | P51679 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | WDR5 | P61964 | 2/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4222151 | 0.89 | CCR2 (0.64) | CCR2CCR1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4258125 | 0.88 | CCR2 (0.61) | CCR2CCR1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3049201 | 0.83 | CCR2 (0.57) | CCR2CCR1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4258139 | 0.80 | MCL1 (0.48) | CCR2WDR5MEN1KMT2A | |
| SCHEMBL8524909 | 0.78 | PTGS1 (0.54) | CCR2CYP3A4CYP2C9CYP1A2ACLY | |
| SCHEMBL3047249 | 0.75 | CCR2 (0.48) | CCR2CCR1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11665908 | 0.74 | BRD4 (0.57) | CYP3A4CYP2C9CYP2C19WDR5MEN1 | |
| SCHEMBL11665915 | 0.74 | BRD4 (0.57) | CYP3A4CYP2C9CYP2C19WDR5MEN1 | |
| SCHEMBL4258133 | 0.72 | FABP4 (0.41) | WDR5MEN1KMT2A | |
| SCHEMBL4081368 | 0.72 | CCR2 (0.60) | CCR2CYP3A4CYP2C9CYP2C19ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074083-A1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-07-01 | — | — | EP | disclosed |
| EP-2057116-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008050167-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008050168-A1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | disclosed |