Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | BRD1 | O95696 | 1/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258125 | 0.82 | CCR2 (0.61) | CCR2ACLYCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3049477 | 0.79 | CCR2 (0.62) | CCR2KMT2A | |
| SCHEMBL3050565 | 0.78 | CCR2 (0.64) | CCR2KMT2A | |
| SCHEMBL4226499 | 0.76 | LMNA (0.53) | CCR2MEN1KMT2A | |
| SCHEMBL9363458 | 0.75 | ALDH1A1 (0.63) | CCR2MEN1KMT2AACLY | |
| SCHEMBL4226495 | 0.74 | LMNA (0.46) | CCR2TRIM24BRD1BRPF1 | |
| SCHEMBL3274322 | 0.74 | CTNNB1 (0.57) | CCR2MEN1KMT2AACLY | |
| SCHEMBL4222151 | 0.74 | CCR2 (0.64) | CCR2ACLYCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2865011 | 0.73 | CTNNB1 (0.58) | MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL31090892 | 0.73 | PTGS1 (0.55) | CCR2MEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057116-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008050167-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | disclosed |