Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | ERN1 | O75460 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | RBM39 | Q14498 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448836 | 0.82 | CASP1 (0.61) | CASP1KMT2AKDM4EGAACA12 | |
| SCHEMBL6448832 | 0.82 | CASP1 (0.61) | CASP1KMT2AKDM4EGAACA12 | |
| SCHEMBL6822831 | 0.82 | CASP1 (0.61) | CASP1KMT2AKDM4EGAACA12 | |
| SCHEMBL30640070 | 0.82 | CASP1 (0.61) | CASP1KMT2AKDM4EGAACA12 | |
| SCHEMBL18372473 | 0.79 | AMY1A (0.53) | KMT2AKDM4EGAAMAPTPOLB | |
| SCHEMBL2320609 | 0.79 | AMY1A (0.53) | KMT2AKDM4EGAAMAPTPOLB | |
| SCHEMBL4346769 | 0.78 | CASP1 (0.62) | CASP1KMT2AKDM4EGAACA12 | |
| SCHEMBL4346774 | 0.78 | CASP1 (0.62) | CASP1KMT2AKDM4EGAACA12 | |
| Ammonia Solution, Strong SCHEMBL10609635 | 0.77 | CASP1 (0.60) | CASP1KMT2AKDM4EGAACA12 | |
| SCHEMBL30495458 | 0.77 | KMT2A (0.69) | CASP1KMT2AKDM4EGAAERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771331-B2 | Methods of identifying neuroprotective compounds for retinal ganglion cells | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-08-27 | — | — | US | disclosed |
| WO-2006113236-A2 | NOVEL CHEMICAL INHIBITORS OF NEUTROPHIL ACTIVATION THROUGH THE SAC-DEPENDENT PATHWAY | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | NLN, GAP43, AIFM1 | CASP1 479/4885KMT2A 4656/4885KDM4E 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.