Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNKP | Q96T60 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4263514 | 0.80 | HSD11B1 (0.40) | HSD11B1KDM4EALDH1A1LMNA | |
| SCHEMBL4264870 | 0.78 | MAPK1 (0.38) | MEN1KMT2AKDM4EALDH1A1KCNJ1 | |
| SCHEMBL4263536 | 0.77 | KCNJ1 (0.42) | TACR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5013447 | 0.77 | PNKP (0.41) | PNKPTACR1EDNRAMEN1KMT2A | |
| SCHEMBL4267976 | 0.77 | HSD11B1 (0.40) | HSD11B1LMNA | |
| SCHEMBL4258668 | 0.77 | KCNJ1 (0.39) | TACR1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1086535 | 0.76 | KCNJ1 (0.47) | TACR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1086474 | 0.75 | ALDH1A1 (0.44) | TACR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1086473 | 0.75 | MAPK1 (0.48) | TACR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1086417 | 0.74 | ALDH1A1 (0.42) | TACR1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |