Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | F2 | P00734 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29643236 | 0.86 | MAPT (0.70) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1586929 | 0.86 | MAPT (0.70) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10738593 | 0.85 | MAPT (0.68) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29643283 | 0.85 | F2 (0.74) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6447738 | 0.85 | F2 (0.74) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4024926 | 0.84 | MEN1 (0.74) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL30523171 | 0.84 | MEN1 (0.74) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4283723 | 0.83 | MAPT (0.66) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11960103 | 0.81 | MEN1 (0.67) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6243452 | 0.81 | MAPT (1.00) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | CORBETT JEFFREY WAYNE | 2009-10-29 | — | — | US | disclosed |
| EP-2097420-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008065508-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, PC, ACACB | MAPT 2999/4885KDM4E 1062/4885SMN1; SMN2 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.