SCHEMBL4258859

SCHEMBL4258859

CCN(CC)c1ccc2cc([C]=O)c(=O)oc2c1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 12/20 0.78
KMT2A Q03164 12/20 0.78
MAPT P10636 12/20 0.78
KDM4E B2RXH2 10/20 0.78
CYP19A1 P11511 3/20 0.69
ALDH1A1 P00352 9/20 0.63
HPGD P15428 5/20 0.63
NPSR1 Q6W5P4 4/20 0.63
ATM Q13315 6/20 0.61
SMN1; SMN2 Q16637 6/20 0.61
USP2 O75604 4/20 0.61
HSD17B10 Q99714 4/20 0.61
MAOB P27338 3/20 0.61
ALOX15 P16050 2/20 0.61
CYP1A2 P05177 1/20 0.61
CYP2C19 P33261 1/20 0.61
SLC16A3 O15427 1/20 0.61
SLC16A1 P53985 1/20 0.61
L3MBTL1 Q9Y468 4/20 0.60
GLA P06280 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6282516 0.87 MEN1 (1.00) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL12495150 0.87 MEN1 (0.76) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL30532621 0.87 MEN1 (1.00) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL28517532 0.84 MEN1 (0.70) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL5169828 0.81 CYP19A1 (0.75) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL2030045 0.81 CYP19A1 (0.75) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL13067106 0.81 CYP19A1 (0.75) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL24589994 0.79 CYP19A1 (0.73) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL3546791 0.79 CYP19A1 (0.73) MEN1KMT2AMAPTKDM4ECYP19A1
SCHEMBL28712885 0.79 CYP19A1 (0.73) MEN1KMT2AMAPTKDM4ECYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4326736-A1 MORPHOLOGICAL MARKER STAINING Ventana Medical Systems, Inc. (US) 2024-02-28 EP disclosed
US-20240043904-A1 MORPHOLOGICAL MARKER STAINING VENTANA MEDICAL SYSTEMS, INC. 2024-02-08 US disclosed
US-20240011099-A1 STAINED BIOLOGICAL SPECIMENS INCLUDING ONE OR MORE BIOMARKERS LABELED WITH ONE OR MORE DETECTABLE MOIETIES VENTANA MED SYST INC (US) 2024-01-11 US disclosed
CN-117177985-A Morphological marker staining 文塔纳医疗系统公司 2023-12-05 CN disclosed
EP-4281779-A1 STAINED BIOLOGICAL SPECIMENS INCLUDING ONE OR MORE BIOMARKERS LABELED WITH ONE OR MORE DETECTABLE MOIETIES Ventana Medical Systems, Inc. (US) 2023-11-29 EP disclosed
CN-116868054-A Stained biological samples comprising one or more biomarkers labeled with one or more detectable moieties 文塔纳医疗系统公司 2023-10-10 CN disclosed
CN-116284747-A Deep delivery of nanomedicines that block tumor innervation and target destruction of cancer cell mitochondria 宁波大学 2023-06-23 CN disclosed
CN-116217925-A Nanometer medicine for inducing mitochondrial dysfunction and reversing multi-medicine resistance by taking red blood cell for stool transport 宁波大学 2023-06-06 CN disclosed
US-20090035796-A1 Enzyme sensors including environmentally sensitive or fluorescent labels and uses thereof THE ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY 2009-02-05 US disclosed
US-20060211075-A1 Enzyme sensors including environmentally sensitive or fluorescent labels and uses thereof THE ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY 2006-09-21 US disclosed
WO-1999032886-A1 GENERIC SIGNALLING MECHANISM FOR DETECTION OF ANALYTES VICAM, L.P. (US) 1999-07-01 WO disclosed