Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | OXTR | P30559 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074922 | 0.88 | KMT2A (0.47) | KMT2AL3MBTL1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL4276208 | 0.85 | KMT2A (0.63) | KMT2AL3MBTL1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL4492023 | 0.84 | OPRM1 (0.45) | KMT2AROCK2 | |
| SCHEMBL19667040 | 0.83 | ATM (0.62) | KMT2AL3MBTL1ATMSMN1; SMN2LMNA | |
| SCHEMBL4080173 | 0.83 | CYP2C9 (0.47) | KMT2AL3MBTL1ATMSMN1; SMN2MEN1 | |
| SCHEMBL4483783 | 0.77 | OPRM1 (0.56) | ALDH1A1 | |
| SCHEMBL1785732 | 0.73 | OPRM1 (0.47) | KMT2AMEN1ROCK2OXTRAVPR1A | |
| SCHEMBL17850457 | 0.73 | KMT2A (0.71) | KMT2AL3MBTL1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL10288644 | 0.73 | KMT2A (0.71) | KMT2AL3MBTL1ATMSMN1; SMN2NPSR1 | |
| Hydrochloric Acid SCHEMBL3345325 | 0.72 | OPRM1 (0.46) | KMT2AMEN1ROCK2OXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |