Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481852 | 0.92 | OPRM1 (0.57) | OPRM1OPRD1OPRK1EGLN1CHUK | |
| SCHEMBL4492023 | 0.90 | OPRM1 (0.45) | OPRM1OPRD1OPRK1EGLN1CHUK | |
| SCHEMBL4075945 | 0.86 | OPRM1 (0.57) | OPRM1OPRD1OPRK1MCHR1OPRL1 | |
| SCHEMBL4071701 | 0.84 | OPRM1 (0.47) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4074406 | 0.83 | OPRM1 (0.46) | OPRM1OPRD1OPRK1EGLN1OPRL1 | |
| SCHEMBL4256842 | 0.81 | OPRM1 (0.45) | OPRM1OPRD1OPRK1EGLN1OPRL1 | |
| SCHEMBL4083677 | 0.81 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1CHRM2 | |
| SCHEMBL4078358 | 0.80 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1CHRM2 | |
| SCHEMBL4965903 | 0.79 | OPRM1 (0.61) | OPRM1OPRD1OPRK1ACHEMCHR1 | |
| SCHEMBL1348506 | 0.78 | OPRM1 (0.42) | OPRM1OPRD1OPRK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |