Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259246 | 0.88 | KMT2A (0.49) | KMT2AKDM4EMEN1L3MBTL1ATM | |
| SCHEMBL4080173 | 0.78 | CYP2C9 (0.47) | KMT2AKDM4EMEN1L3MBTL1ATM | |
| SCHEMBL4276208 | 0.78 | KMT2A (0.63) | KMT2AKDM4EMEN1L3MBTL1ATM | |
| SCHEMBL4074422 | 0.77 | OPRM1 (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDCYP2C19 | |
| SCHEMBL19667040 | 0.76 | ATM (0.62) | KMT2AKDM4EL3MBTL1ATMALDH1A1 | |
| SCHEMBL4081847 | 0.75 | OPRM1 (0.54) | — | |
| SCHEMBL4492023 | 0.73 | OPRM1 (0.45) | KMT2ANPC1RAB9A | |
| SCHEMBL8240258 | 0.67 | HDAC1 (0.51) | KMT2ACYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL2333286 | 0.67 | SMN1; SMN2 (0.52) | KMT2AKDM4EMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL4483783 | 0.67 | OPRM1 (0.56) | ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |