Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259946 | 1.00 | KDM1A (0.51) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL5054677 | 1.00 | KDM1A (0.51) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL7366357 | 0.93 | KDM1A (0.55) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL7366355 | 0.93 | KDM1A (0.55) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL4254701 | 0.92 | KDM1A (0.54) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL4254703 | 0.92 | KDM1A (0.54) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL2826447 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 | |
| SCHEMBL1380697 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 | |
| SCHEMBL1380700 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 | |
| SCHEMBL4260439 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833782-B1 | CYCLOALKYLAMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | EP | disclosed |
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1147089-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042020-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |