Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259946 | 1.00 | KDM1A (0.51) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL4259945 | 1.00 | KDM1A (0.51) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL7366357 | 0.93 | KDM1A (0.55) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL7366355 | 0.93 | KDM1A (0.55) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL4254701 | 0.92 | KDM1A (0.54) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL4254703 | 0.92 | KDM1A (0.54) | KDM1APDE4AALDH1A1HPGDKDM4E | |
| SCHEMBL2826447 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 | |
| SCHEMBL1380697 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 | |
| SCHEMBL1380700 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 | |
| SCHEMBL4260439 | 0.88 | KDM1A (0.51) | KDM1APDE4AALDH1A1PDE4BDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214536-A1 | Amido-Substituted 6-Phenylphenanthridines | NYCOMED GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
| US-20080119505-A1 | Novel 6-Pyridylphenanthridines | ALTANA PHARMA AG (DE) | 2008-05-22 | — | — | US | disclosed |
| EP-1858880-A1 | AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES | Nycomed GmbH (DE) | 2007-11-28 | — | — | EP | disclosed |
| EP-1846390-A1 | NOVEL 6-PYRIDYLPHENANTHRIDINES | Nycomed GmbH (DE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006095009-A1 | AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES | NYCOMED GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
| WO-2006082185-A1 | NOVEL 6-PYRIDYLPHENANTHRIDINES | NYCOMED GMBH (DE) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119505-A1 | Novel 6-Pyridylphenanthridines | PDE4A, PDE4B, PDE4C | KDM1A 901/4885PDE4A 1/4885ALDH1A1 168/4885 |
| US-20080214536-A1 | Amido-Substituted 6-Phenylphenanthridines | PDE4A, PDE4B, PDE3A | KDM1A 1058/4885PDE4A 1/4885ALDH1A1 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.