Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997743 | 0.77 | CREBBP (0.43) | USP2SMN1; SMN2MAPK1ESR2NR1H2 | |
| SCHEMBL4260445 | 0.73 | PIK3CD (0.39) | HTR2AHTR2CHTR1AHTR1DUSP2 | |
| Indole SCHEMBL4414195 | 0.72 | C5AR1 (0.43) | USP2SMN1; SMN2MAPK1PRMT5WDR77 | |
| SCHEMBL19667310 | 0.71 | USP2 (0.44) | USP2SMN1; SMN2MAPK1GPR119ESR2 | |
| SCHEMBL2001858 | 0.70 | CREBBP (0.35) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL17813928 | 0.70 | USP2 (0.43) | USP2SMN1; SMN2MAPK1GPR119ESR2 | |
| SCHEMBL3276399 | 0.70 | UCHL1 (0.44) | USP2SMN1; SMN2MAPK1GPR119ESR2 | |
| SCHEMBL17813927 | 0.70 | NR1H2 (0.44) | USP2SMN1; SMN2MAPK1PIK3CDGPR119 | |
| SCHEMBL22744298 | 0.69 | POLB (0.43) | USP2SMN1; SMN2MAPK1GPR119NR1H2 | |
| SCHEMBL1998581 | 0.69 | OPRK1 (0.34) | USP2SMN1; SMN2GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091953-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4]OXAZEPINO [6, 7-E]INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (publ) (SE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |