Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42618 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTLMNAALDH1A1MAPT | |
| SCHEMBL38657 | 0.90 | LMNA (0.45) | SMN1; SMN2HTTLMNAALDH1A1MAPT | |
| SCHEMBL47283 | 0.90 | MAPT (0.44) | SMN1; SMN2HTTLMNAALDH1A1MAPT | |
| SCHEMBL38750 | 0.89 | NPC1 (0.52) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10119596 | 0.89 | NPC1 (0.52) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL38704 | 0.89 | ALDH1A1 (0.44) | SMN1; SMN2LMNAALDH1A1MAPTNPC1 | |
| SCHEMBL38769 | 0.89 | ALDH1A1 (0.44) | SMN1; SMN2LMNAALDH1A1MAPTNPC1 | |
| SCHEMBL47284 | 0.87 | MAPT (0.53) | SMN1; SMN2HTTLMNAALDH1A1MAPT | |
| SCHEMBL47173 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTLMNAALDH1A1MAPT | |
| SCHEMBL47281 | 0.81 | TMPRSS15 (0.43) | SMN1; SMN2HTTLMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426390-B2 | Triazene compounds for the treatment of cancer | TRIN THERAPEUTICS GMBH (DE) | 2013-04-23 | — | — | US | disclosed |
| US-20120028927-A1 | Novel Triazene Compounds For The Treatment Of Cancer | TRIN THERAPEUTICS GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
| US-8034797-B2 | Triazene compounds for the treatment of cancer | TRIN THERAPEUTICS GMBH (DE) | 2011-10-11 | — | — | US | disclosed |
| US-20100234327-A1 | Novel Triazene Compounds For The Treatment Of Cancer | TRIN PHARMA GMBH (CH) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234327-A1 | Novel Triazene Compounds For The Treatment Of Cancer | KRAS, TP53, VHL | SMN1; SMN2 2078/4885HTT 915/4885LMNA 2884/4885 |
| US-20120028927-A1 | Novel Triazene Compounds For The Treatment Of Cancer | KRAS, TP53, VHL | SMN1; SMN2 2078/4885HTT 915/4885LMNA 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.