Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 11/20 | 0.69 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265352 | 0.89 | RIPK2 (0.61) | RIPK2SRCKDRPDGFRBLCK | |
| SCHEMBL4255774 | 0.89 | RIPK2 (0.59) | RIPK2SRCFLT3CSF1RFLT1 | |
| SCHEMBL4260583 | 0.87 | KDR (0.55) | RIPK2SRCFLT3CSF1RFLT1 | |
| SCHEMBL4260093 | 0.86 | AURKB (0.63) | FLT3CSF1RFLT1KDRPDGFRB | |
| SCHEMBL4265907 | 0.86 | RIPK2 (0.61) | RIPK2SRCKDRPDGFRBLCK | |
| SCHEMBL4262460 | 0.86 | RIPK2 (0.74) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL4257241 | 0.84 | RIPK2 (0.55) | RIPK2SRCKDRPDGFRBLCK | |
| SCHEMBL4263207 | 0.84 | RIPK2 (0.56) | RIPK2SRCFLT3KDRPDGFRB | |
| SCHEMBL4261322 | 0.82 | RIPK2 (0.59) | RIPK2SRC | |
| SCHEMBL4261383 | 0.81 | RIPK2 (0.76) | RIPK2SRCKDRLCKTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307097-B2 | Chemical compounds | SMITHKLINE BEECHMAN CORPORATION (US) | 2007-12-11 | — | — | US | claimed |
| EP-1436265-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | claimed |
| US-20040198986-A1 | 5-amino-1,3-substituted pyrazole-4-carboxylic acid amides of given formula, such as 5-Amino-1-tert-butyl-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-1H-pyrazole-4-carboxylic acid amide; treating cancer; receptor tyrosine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-10-07 | — | — | US | claimed |
| EP-1436265-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003072541-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-04 | — | — | WO | claimed |
| US-20090012309-A1 | CHEMICAL COMPOUNDS | ADAMS JERRY LEROY | 2009-01-08 | — | — | US | disclosed |
| US-7307097-B2 | Chemical compounds | SMITHKLINE BEECHMAN CORPORATION (US) | 2007-12-11 | — | — | US | disclosed |
| US-20040198986-A1 | 5-amino-1,3-substituted pyrazole-4-carboxylic acid amides of given formula, such as 5-Amino-1-tert-butyl-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-1H-pyrazole-4-carboxylic acid amide; treating cancer; receptor tyrosine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012309-A1 | CHEMICAL COMPOUNDS | CYP11B2, CYP3A43, CYP3A5 | RIPK2 2720/4885SRC 3149/4885FLT3 472/4885 |
| US-20040198986-A1 | 5-amino-1,3-substituted pyrazole-4-carboxylic acid amides of given formula, such as 5-Amino-1-tert-butyl-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-1H-pyrazole-4-carboxylic acid amide; treating cancer; receptor tyrosine kinase inhibitors | ERBB2, RET, ERBB4 | RIPK2 786/4885SRC 32/4885FLT3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.