Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.54 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | FLT1 | P17948 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | LYN | P07948 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 4/20 | 0.51 |
| ▸ | FLT4 | P35916 | 4/20 | 0.51 |
| ▸ | BLK | P51451 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602055 | 0.92 | MEN1 (0.53) | KDRPDGFRBSRCFLT1LCK | |
| SCHEMBL4260556 | 0.91 | RIPK2 (0.53) | KDRPDGFRBRIPK2EPHA3EPHB4 | |
| SCHEMBL4257173 | 0.88 | KDR (0.58) | KDRPDGFRBEPHA3EPHB4SRC | |
| SCHEMBL6614917 | 0.88 | RIPK2 (0.51) | KDRPDGFRBRIPK2EPHA3EPHB4 | |
| SCHEMBL6614602 | 0.87 | RIPK2 (0.50) | KDRPDGFRBRIPK2EPHA3EPHB4 | |
| SCHEMBL4261925 | 0.87 | RIPK2 (0.69) | KDRPDGFRBRIPK2SRCFLT1 | |
| SCHEMBL4255774 | 0.86 | RIPK2 (0.59) | KDRPDGFRBRIPK2SRCFLT1 | |
| SCHEMBL4258858 | 0.86 | RET (0.55) | KDRPDGFRBSRCFLT1LCK | |
| SCHEMBL4262663 | 0.85 | RIPK2 (0.58) | KDRRIPK2SRCFLT1LCK | |
| SCHEMBL6613292 | 0.85 | KDR (0.55) | KDRPDGFRBEPHA3EPHB4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307097-B2 | Chemical compounds | SMITHKLINE BEECHMAN CORPORATION (US) | 2007-12-11 | — | — | US | claimed |
| US-20040198986-A1 | 5-amino-1,3-substituted pyrazole-4-carboxylic acid amides of given formula, such as 5-Amino-1-tert-butyl-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-1H-pyrazole-4-carboxylic acid amide; treating cancer; receptor tyrosine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-10-07 | — | — | US | claimed |
| US-20090012309-A1 | CHEMICAL COMPOUNDS | ADAMS JERRY LEROY | 2009-01-08 | — | — | US | disclosed |
| US-7307097-B2 | Chemical compounds | SMITHKLINE BEECHMAN CORPORATION (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1436265-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | disclosed |
| US-20040198986-A1 | 5-amino-1,3-substituted pyrazole-4-carboxylic acid amides of given formula, such as 5-Amino-1-tert-butyl-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-1H-pyrazole-4-carboxylic acid amide; treating cancer; receptor tyrosine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-10-07 | — | — | US | disclosed |
| EP-1436265-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003072541-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012309-A1 | CHEMICAL COMPOUNDS | CYP11B2, CYP3A43, CYP3A5 | KDR 3847/4885PDGFRB 2728/4885RIPK2 2720/4885 |
| US-20040198986-A1 | 5-amino-1,3-substituted pyrazole-4-carboxylic acid amides of given formula, such as 5-Amino-1-tert-butyl-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-1H-pyrazole-4-carboxylic acid amide; treating cancer; receptor tyrosine kinase inhibitors | ERBB2, RET, ERBB4 | KDR 191/4885PDGFRB 67/4885RIPK2 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.