Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metaraminol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 1.00 |
| ▸ | MIF | P14174 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.78 |
| ▸ | LMNA | P02545 | 6/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metaraminol SCHEMBL29379078 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL11417827 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL136778 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL19169701 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL3148045 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL31144506 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL5172992 | 1.00 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL3148038 | 0.98 | ADRB1 (0.96) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL10892040 | 0.98 | ADRB1 (0.96) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL16241612 | 0.98 | ADRB1 (0.96) | ADRB1ADRA1AMIFHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199516-B1 | PROCESS FOR THE PREPARATION OF METARAMINOL | LABORATORI ALCHEMIA S R L (IT) | 2019-07-24 | — | — | EP | disclosed |
| EP-3199516-A1 | PROCESS FOR THE PREPARATION OF METARAMINOL | Laboratori Alchemia S.R.L. (IT) | 2017-08-02 | — | — | EP | disclosed |
| US-20170210696-A1 | Process for the Preparation of Metaraminol | LABORATORI ALCHEMIA S.R.L. (IT) | 2017-07-27 | — | — | US | disclosed |
| US-20170210696-A1 | Process for the Preparation of Metaraminol | LABORATORI ALCHEMIA S.R.L. (IT) | 2017-07-27 | — | — | US | disclosed |
| US-20090042275-A1 | NOVEL PLASMIDS AND UTILIZATION THEREOF | DAIICHI FINE CHEMICAL CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| EP-1273665-B1 | PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS | DAIICHI FINE CHEM CO LTD (JP) | 2007-05-16 | — | — | EP | disclosed |
| US-6835559-B2 | Process for the production of optically active β-amino alcohols | DAIICHI FINE CHEMICAL CO., LTD. (JP) | 2004-12-28 | — | — | US | disclosed |
| US-20040091981-A1 | Process for the production of optically active beta-amino alcohols | DAIICHI FINE CHEMICAL CO., LTD. (JP) | 2004-05-13 | — | — | US | disclosed |
| EP-1273665-A1 | PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS | Daiichi Fine Chemical Co., Ltd. (JP) | 2003-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210696-A1 | Process for the Preparation of Metaraminol | MSMO1, METAP1, M6PR | ADRA1A 843/4885ADRA1B 617/4885ADRB1 511/4885 |
| US-20090042275-A1 | NOVEL PLASMIDS AND UTILIZATION THEREOF | COASY, BLVRB, TKT | ADRA1A 2061/4885ADRA1B 1866/4885ADRB1 1554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.