Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.35 |
| ▸ | CCR8 | P51685 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23631763 | 0.99 | KDM4E (0.34) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL23631760 | 0.99 | KDM4E (0.34) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL450417 | 0.88 | HDAC8 (0.35) | RAB9AHDAC8 | |
| SCHEMBL599823 | 0.82 | KDM4E (0.52) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL2867444 | 0.77 | KDM4E (0.50) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL22645657 | 0.77 | KDM4E (0.50) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL4413920 | 0.74 | KDM4E (0.43) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL4409178 | 0.74 | KDM4E (0.43) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL4407509 | 0.74 | KDM4E (0.43) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL4410148 | 0.74 | KDM4E (0.43) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485721-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080207582-A1 | Substituted Porphyrins | DUKE UNIVERSITY (US) | 2008-08-28 | — | — | US | disclosed |
| US-20040058902-A1 | Substituted porphyrins | DUKE UNIVERSITY | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207582-A1 | Substituted Porphyrins | SOD3, MPO, SOD1 | KDM4E 2112/4885LMNA 2896/4885CCR1 4333/4885 |
| US-20040058902-A1 | Substituted porphyrins | SOD1, SOD3, CAT | KDM4E 2083/4885LMNA 2264/4885CCR1 2903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.