Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 19/20 | 0.70 |
| ▸ | PTPRF | P10586 | 1/20 | 0.48 |
| ▸ | PTPRA | P18433 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261546 | 0.84 | SIRT3 (0.62) | PTPN1 | |
| SCHEMBL5764063 | 0.81 | PTPN1 (0.83) | PTPN1 | |
| SCHEMBL4275342 | 0.80 | PTPN1 (0.64) | PTPN1 | |
| SCHEMBL7498451 | 0.79 | PTPN1 (1.00) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL7499262 | 0.79 | PTPN1 (1.00) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL4270758 | 0.75 | PTPN1 (0.59) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL4270762 | 0.75 | PTPN1 (0.59) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL6730825 | 0.74 | PTPN1 (0.93) | PTPN1 | |
| SCHEMBL4268144 | 0.73 | PTPN1 (0.57) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL4268141 | 0.73 | PTPN1 (0.57) | PTPN1PTPRFPTPRAPTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082392-A1 | Substituted Carboxylic Acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2009-03-26 | — | — | US | claimed |
| US-20040266788-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-30 | — | — | US | claimed |
| US-20090082392-A1 | Substituted Carboxylic Acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2009-03-26 | — | — | US | disclosed |
| US-7358364-B2 | treatment of diabetes and/or cancer; useful in the treatment of syndrome X; capable of inhibiting Protein tyrosine phosphatase | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| US-20040266788-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266788-A1 | Substituted carboxylic acids | PTP4A1, PTPRS, G6PC1 | PTPN1 11/4885PTPRF 8/4885PTPRA 13/4885 |
| US-20090082392-A1 | Substituted Carboxylic Acids | PTPRJ, PTPRS, PTPRG | PTPN1 16/4885PTPRF 6/4885PTPRA 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.