SCHEMBL4264276

SCHEMBL4264276

CCOC(=O)c1ccc(N2CN3CCNCC3C2=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 13/20 0.47
POLB P06746 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HSP90AA1 P07900 4/20 0.46
MAPK1 P28482 2/20 0.46
HTT P42858 4/20 0.44
HPGD P15428 5/20 0.44
NPSR1 Q6W5P4 2/20 0.44
CACNA1B Q00975 1/20 0.44
APBA1 Q02410 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
MAPT P10636 3/20 0.43
TSHR P16473 2/20 0.43
KDM4E B2RXH2 2/20 0.43
USP2 O75604 2/20 0.43
MEN1 O00255 1/20 0.43
ALOX12 P18054 1/20 0.43
RECQL P46063 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3607615 0.99 ALDH1A1 (0.47) ALDH1A1POLBSMN1; SMN2HSP90AA1MAPK1
SCHEMBL4266777 0.87 ATM (0.52) ALDH1A1POLBSMN1; SMN2KMT2AALOX15
Hydrochloric Acid SCHEMBL3593431 0.86 ATM (0.51) ALDH1A1POLBSMN1; SMN2KMT2AALOX15
Hydrochloric Acid SCHEMBL3610738 0.81 HTR2A (0.39) ALDH1A1POLBSMN1; SMN2NPSR1MEN1
Bromide SCHEMBL3602839 0.80 MAPT (0.42) ALDH1A1SMN1; SMN2MAPK1HPGDTDP1
SCHEMBL4264273 0.76 ALDH1A1 (0.44) ALDH1A1POLBSMN1; SMN2HSP90AA1MAPK1
SCHEMBL30557800 0.76 ALDH1A1 (0.44) ALDH1A1POLBSMN1; SMN2HSP90AA1MAPK1
SCHEMBL3604176 0.75 ALDH1A1 (0.42) ALDH1A1POLBSMN1; SMN2HSP90AA1MAPK1
SCHEMBL25240100 0.75 ALDH1A1 (0.51) ALDH1A1POLBSMN1; SMN2HSP90AA1MAPK1
Hydrochloric Acid SCHEMBL3607612 0.75 ALDH1A1 (0.43) ALDH1A1POLBSMN1; SMN2HSP90AA1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2039695-A1 BICYCLIC HETEROCYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2009-03-25 EP disclosed