Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | SDHB | P21912 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222690 | 0.80 | GRM5 (0.44) | MERTKGRM5RIPK1KDM4EALDH1A1 | |
| SCHEMBL4228716 | 0.75 | TLR7 (0.48) | TLR7TLR9TLR8KDM4EALDH1A1 | |
| SCHEMBL4262106 | 0.75 | TLR7 (0.45) | EGFRCYP3A4KCNH2TLR7TLR9 | |
| SCHEMBL4263914 | 0.73 | MERTK (0.38) | EGFRMERTKTLR7TLR9TLR8 | |
| SCHEMBL4266481 | 0.70 | TLR7 (0.48) | EGFRTLR7TLR9TLR8GRM5 | |
| SCHEMBL4048899 | 0.70 | JAK2 (0.52) | KCNH2TLR7TLR9TLR8PIK3CA | |
| SCHEMBL4261932 | 0.68 | CYP17A1 (0.44) | EGFRCYP3A4TLR7TLR9TLR8 | |
| SCHEMBL4255983 | 0.68 | CA12 (0.40) | TLR9RIPK1USP2ALDH1A1LMNA | |
| SCHEMBL30881473 | 0.68 | ALOX5 (0.47) | EGFRMERTKKDM4EALDH1A1LMNA | |
| SCHEMBL27244011 | 0.68 | ALOX5 (0.47) | EGFRMERTKKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | EGFR 1469/4885CYP3A4 957/4885BRAF 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.