Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245392 | 0.86 | GSK3B (0.43) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL3004313 | 0.78 | ALDH1A1 (0.56) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL3009592 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL3005544 | 0.77 | CACNA1C (0.45) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL2999733 | 0.76 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL2996950 | 0.76 | PDE1C (0.45) | HSD17B10GAAADORA3TSHRBLM | |
| SCHEMBL3001176 | 0.76 | DHFR (0.66) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL7257040 | 0.76 | KDM4E (0.60) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL4257958 | 0.74 | CACNA1C (0.46) | KDM4EALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL4252896 | 0.74 | MAPT (0.48) | KDM4EALDH1A1HSD17B10LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |