Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29155320 | 0.72 | SIGMAR1 (0.45) | HTR6SIGMAR1KDM4EKMT2AACHE | |
| SCHEMBL13382859 | 0.71 | ITGB3 (0.52) | ITGB3ITGA2BKDM4E | |
| SCHEMBL4266289 | 0.71 | CNR1 (0.59) | TSHRKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL13172360 | 0.70 | SMN1; SMN2 (0.55) | HSD17B10KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL20886930 | 0.69 | SMN1; SMN2 (0.60) | HTR6HTR1AHTR7HTR1DHTR1B | |
| SCHEMBL4678247 | 0.69 | KMT2A (0.56) | HTR6HTR1AHTR7HTR1DHTR1B | |
| SCHEMBL4360123 | 0.68 | FAAH (0.38) | HTR1ASIGMAR1HPGD | |
| SCHEMBL4363957 | 0.68 | P2RY12 (0.41) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4678245 | 0.68 | KMT2A (0.55) | HTR6HTR1AHTR7HTR1DHTR1B | |
| SCHEMBL10982828 | 0.68 | USP2 (0.40) | SIGMAR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056828-A2 | SULFONYLATED PIPERAZINES AS CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024284-A2 | SULFONYLATED PIPERAZINES AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-02-28 | — | — | WO | disclosed |