Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425814 | 0.86 | SIGMAR1 (0.40) | SIGMAR1HTR2BDDR2HTR1AHTR1D | |
| SCHEMBL425404 | 0.86 | KMO (0.45) | SIGMAR1DDR2L3MBTL1KDM4EMEN1 | |
| SCHEMBL430389 | 0.86 | DDR2 (0.42) | SIGMAR1HTR2BDDR2L3MBTL1KDM4E | |
| SCHEMBL430391 | 0.86 | DDR2 (0.42) | SIGMAR1HTR2BDDR2L3MBTL1KDM4E | |
| SCHEMBL425402 | 0.86 | KMO (0.45) | SIGMAR1DDR2L3MBTL1KDM4EMEN1 | |
| SCHEMBL425820 | 0.86 | MRGPRX4 (0.47) | MAPTSMN1; SMN2SIGMAR1DDR2L3MBTL1 | |
| SCHEMBL425347 | 0.85 | DDR2 (0.42) | SMN1; SMN2SIGMAR1DDR2HTR1AL3MBTL1 | |
| SCHEMBL425345 | 0.85 | DDR2 (0.42) | SMN1; SMN2SIGMAR1DDR2HTR1AL3MBTL1 | |
| SCHEMBL425298 | 0.84 | L3MBTL1 (0.48) | MAPTHTTSMN1; SMN2SIGMAR1PIK3CA | |
| SCHEMBL425301 | 0.84 | CASR (0.42) | SIGMAR1DDR2L3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687004-A4 | PYRIDINE COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2009-04-08 | — | — | EP | claimed |
| JP-2007510747-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1687004-A2 | PYRIDINE COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2006-08-09 | — | — | EP | claimed |
| WO-2005046603-A2 | PYRIDINE COMPOUNDS | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-05-26 | — | — | WO | claimed |
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |