Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BID | P55957 | 6/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.58 |
| ▸ | BAK1 | Q16611 | 5/20 | 0.58 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.58 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
| ▸ | EP300 | Q09472 | 1/20 | 0.58 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.58 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.58 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | F7 | P08709 | 2/20 | 0.50 |
| ▸ | F3 | P13726 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9815548 | 0.94 | BID (0.57) | BIDMCL1BCL2L1BAK1KAT8 | |
| Benzene SCHEMBL9052791 | 0.94 | HTR1A (0.58) | BIDMCL1BCL2L1BAK1KAT8 | |
| Bicarbonate SCHEMBL9175297 | 0.93 | BID (0.69) | BIDMCL1BCL2L1BAK1KAT8 | |
| Bicarbonate SCHEMBL9170233 | 0.93 | BID (0.69) | BIDMCL1BCL2L1BAK1KAT8 | |
| Bicarbonate SCHEMBL4863706 | 0.93 | BID (0.69) | BIDMCL1BCL2L1BAK1KAT8 | |
| Propionic Acid SCHEMBL8222391 | 0.93 | BID (0.55) | BIDMCL1BCL2L1BAK1KAT8 | |
| Acetone SCHEMBL25277794 | 0.92 | BID (0.54) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL29450060 | 0.92 | HTR1A (0.60) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL20232 | 0.92 | HTR1A (0.60) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL9319489 | 0.92 | HTR1A (0.60) | BIDMCL1BCL2L1BAK1KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322919-A | Transesterification in an inert solvent | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 1994-06-21 | — | — | US | claimed |
| EP-3692090-A1 | IMPROVED METHOD OF MODIFYING A POLYCARBONATE DURING A MELT POLYMERIZATION | SABIC Global Technologies B.V. (NL) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019069207-A1 | IMPROVED METHOD OF MODIFYING A POLYCARBONATE DURING A MELT POLYMERIZATION | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-04-11 | — | — | WO | disclosed |
| EP-1760085-B1 | PROCESS FOR PRODUCTION OF ALKYLTIN ALKOXIDES | ASAHI KASEI CHEMICALS CORP (JP) | 2014-02-26 | — | — | EP | disclosed |
| US-7541482-B2 | Process for production of alkyltin alkoxides | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20080275262-A1 | Process for Production of Alkyltin Alkoxides | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2008-11-06 | — | — | US | disclosed |
| EP-1760085-A1 | PROCESS FOR PRODUCTION OF ALKYLTIN ALKOXIDES | Asahi Kasei Chemicals Corporation (JP) | 2007-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275262-A1 | Process for Production of Alkyltin Alkoxides | ALK, MOGAT2, SOAT2 | BID 967/4885MCL1 344/4885BCL2L1 2692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.