Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | USP14 | P54578 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419738 | 0.81 | ALDH1A1 (0.56) | KCNA3DRD2DRD3CKS1BSKP1 | |
| SCHEMBL4272900 | 0.79 | KCNA3 (0.49) | KCNA3DRD2DRD3CCR5USP14 | |
| SCHEMBL27226915 | 0.78 | SIGMAR1 (0.59) | KCNA3DRD2DRD3KMT2AL3MBTL1 | |
| SCHEMBL4700826 | 0.78 | PARP1 (0.50) | KCNA3DRD2DRD3HDAC3HDAC1 | |
| SCHEMBL20227779 | 0.77 | NR1H2 (0.55) | KCNA3DRD2UBE2MDCUN1D1 | |
| SCHEMBL29998921 | 0.77 | NR1H2 (0.55) | KCNA3DRD2UBE2MDCUN1D1 | |
| SCHEMBL22928915 | 0.77 | KCNA3 (0.66) | KCNA3DRD2DRD3CCR5CKS1B | |
| SCHEMBL30915133 | 0.76 | DRD2 (0.52) | KCNA3DRD2DRD3CCR5CKS1B | |
| SCHEMBL30981429 | 0.76 | KCNA3 (0.54) | KCNA3DRD2DRD3CCR5USP14 | |
| SCHEMBL30902424 | 0.76 | DRD2 (0.49) | KCNA3DRD2DRD3CCR5HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |
| EP-1730130-A1 | BETA-KETOAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING SAID COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| US-20050245500-A1 | Beta-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-03 | — | — | US | disclosed |
| WO-2005085221-A1 | BETA-KETOAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING SAID COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245500-A1 | Beta-ketoamide compounds with MCH antagonistic activity | MCHR2, MCHR1, NPY1R | KCNA3 401/4885DRD2 619/4885DRD3 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.