Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.69 |
| ▸ | BCR | P11274 | 7/20 | 0.69 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.58 |
| ▸ | PRKCA | P17252 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269273 | 0.88 | ABL1 (0.66) | ABL1BCRKARS1PRKCAEGFR | |
| SCHEMBL3565337 | 0.83 | ABL1 (0.66) | ABL1BCRKARS1PRKCAGAA | |
| SCHEMBL29555505 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL29366999 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL2392 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4264785 | 0.81 | KARS1 (0.54) | ABL1BCRKARS1PRKCAEGFR | |
| Hydrochloric Acid SCHEMBL2419016 | 0.81 | ABL1 (0.98) | ABL1BCRPRKCAEGFRSRC | |
| Ammonia Solution, Strong SCHEMBL4749564 | 0.81 | ABL1 (0.98) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL14041713 | 0.80 | ABL1 (0.75) | ABL1BCRPRKCAEGFRGAA | |
| SCHEMBL2924553 | 0.79 | ABL1 (0.64) | ABL1BCRKARS1PRKCAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674901-B2 | Process for preparation of imatinib base | INSTYTUT FARMACEUTYCZNY (PL) | 2010-03-09 | — | — | US | disclosed |
| US-7674901-B2 | Process for preparation of imatinib base | INSTYTUT FARMACEUTYCZNY (PL) | 2010-03-09 | — | — | US | disclosed |
| EP-1533304-B1 | AMIDE DERIVATIVE | NIPPON SHINYAKU CO LTD (JP) | 2009-11-04 | — | — | EP | disclosed |
| US-7494997-B2 | Amide derivative | NIPPON SHINYAKU CO., LTD. (JP) | 2009-02-24 | — | — | US | disclosed |
| US-20060014742-A1 | Amide derivative | NIPPON SHINYAKU CO., LTD. (JP) | 2006-01-19 | — | — | US | disclosed |
| EP-1533304-A1 | AMIDE DERIVATIVE | Nippon Shinyaku Co., Ltd. (JP) | 2005-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014742-A1 | Amide derivative | ABL1, ABL2, BCR | ABL1 1/4885BCR 3/4885KARS1 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.